Dimensions in cell migration

Curr Opin Cell Biol. 2013 Oct;25(5):642-9. doi: 10.1016/j.ceb.2013.06.004. Epub 2013 Jul 10.


The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depends profoundly on the dimensionality of the extracellular matrix (ECM). Here we review a number of evolving concepts revealed when cell migration is examined in different dimensions.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Cell Movement*
  • Cell Physiological Phenomena
  • Extracellular Matrix / chemistry
  • Extracellular Matrix / metabolism
  • Humans
  • Signal Transduction