Chronic Norovirus Infection in a Transplant Patient Successfully Treated With Enterally Administered Immune Globulin

J Clin Virol. 2013 Sep;58(1):306-8. doi: 10.1016/j.jcv.2013.06.009. Epub 2013 Jul 10.


Norovirus infection causes a significant burden of morbidity and (in the developing world) mortality. In immunocompromised hosts, norovirus infection can become chronic, with devastating consequences. Unfortunately, therapeutic options for chronic disease are unproven, and treatment is largely supportive. We report a case of norovirus infection causing debilitating chronic gastroenteritis in a transplant patient that responded to a short course of enterally administered human immune globulin.

Keywords: Chronic norovirus; Immunoglobulin; Therapy.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Antibodies, Viral / administration & dosage*
  • Caliciviridae Infections / therapy*
  • Caliciviridae Infections / virology
  • Chronic Disease
  • Female
  • Gastroenteritis / therapy*
  • Gastroenteritis / virology
  • Humans
  • Immunotherapy / methods
  • Middle Aged
  • Norovirus / isolation & purification*
  • Transplantation
  • Treatment Outcome


  • Antibodies, Viral