Active ion transporters from readily accessible acyclic octapeptides containing 3-aminobenzoic acid and alanine

Chem Commun (Camb). 2013 Aug 25;49(66):7340-2. doi: 10.1039/c3cc44224a.

Abstract

Ion transporters have been developed from acyclic octapeptides comprising L/D alanine and m-aminobenzoic acid. These octapeptides transport cations up to 3 times faster than their cyclic analog through lipid vesicles. Preliminary CD, XRD and computational studies allude to a 6-9 Å wide tetrameric ion channel as the active ion transporter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine / chemistry*
  • Circular Dichroism
  • Cyclization
  • Ion Transport
  • Models, Biological
  • Molecular Structure
  • Peptides / chemistry*
  • meta-Aminobenzoates / chemistry*

Substances

  • Peptides
  • meta-Aminobenzoates
  • 3-aminobenzoic acid
  • Alanine