Impaired hippocampal rate coding after lesions of the lateral entorhinal cortex

Nat Neurosci. 2013 Aug;16(8):1085-93. doi: 10.1038/nn.3462. Epub 2013 Jul 14.


In the hippocampus, spatial and non-spatial parameters may be represented by a dual coding scheme, in which coordinates in space are expressed by the collective firing locations of place cells and the diversity of experience at these locations is encoded by orthogonal variations in firing rates. Although the spatial signal may reflect input from medial entorhinal cortex, the sources of the variations in firing rate have not been identified. We found that rate variations in rat CA3 place cells depended on inputs from the lateral entorhinal cortex (LEC). Hippocampal rate remapping, induced by changing the shape or the color configuration of the environment, was impaired by lesions in those parts of the ipsilateral LEC that provided the densest input to the hippocampal recording position. Rate remapping was not observed in LEC itself. The findings suggest that LEC inputs are important for efficient rate coding in the hippocampus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Afferent Pathways / physiopathology
  • Animals
  • CA3 Region, Hippocampal / physiopathology*
  • Color
  • Entorhinal Cortex / drug effects
  • Entorhinal Cortex / injuries
  • Entorhinal Cortex / physiopathology*
  • Environment
  • Exploratory Behavior / physiology
  • Male
  • Memory, Episodic
  • N-Methylaspartate / toxicity
  • Neuronal Plasticity
  • Neurons / physiology*
  • Neurotoxins / toxicity
  • Patch-Clamp Techniques
  • Pyramidal Cells / physiology
  • Rats
  • Rats, Long-Evans
  • Space Perception / physiology*
  • Spatial Behavior / physiology


  • Neurotoxins
  • N-Methylaspartate