[Alkaline phosphatase activity in blood group B or O secretors is fluctuated by the dinner intake of previous night]

Rinsho Byori. 2013 Apr;61(4):307-12.
[Article in Japanese]

Abstract

We previously reported that two intestinal alkaline phosphatase (IAP) isoforms, high molecular mass IAP (HIAP) and normal molecular mass IAP (NIAP), appear in healthy serum with our Triton-PAGE method for determination of ALP isozymes. In addition, HIAP is chiefly present in blood group B or O secretors, and a large amount of NIAP is secreted into the circulation after high-fat meal in blood group B or O secretors. In the present paper, we investigated the relationship between alkaline phosphatase (ALP) activity in early morning with the patient in a fasted state and the dinner intake of previous night. Two types of dinner were prepared; a low-fat meal (520 kcal), and a high-fat meal (1,040 kcal). Subjects ate the 2 types of dinner on different days. The mean ALP activities at 14 h after high-fat meal ingestion in blood group B or O secretors (n=14) from JSCC and IFCC methods were 8.8% and 5.2% higher than those at 14 h after low-fat meal ingestion in blood group B or O secretors, respectively. The increases in ALP activity between after high-fat meal and low-fat meal were nearly identical to the increases in NIAP activity. These results suggest that a high-fat meal is more likely to affect ALP activity at the early morning with the patient in a fasted state in blood group B or O secretors.

Publication types

  • English Abstract

MeSH terms

  • ABO Blood-Group System*
  • Alkaline Phosphatase / metabolism*
  • Energy Intake / physiology*
  • Humans
  • Isoenzymes / metabolism
  • Meals*
  • Time Factors

Substances

  • ABO Blood-Group System
  • Isoenzymes
  • Alkaline Phosphatase