High prevalence of osteoporosis in patients with chronic pancreatitis: a systematic review and meta-analysis

Clin Gastroenterol Hepatol. 2014 Feb;12(2):219-28. doi: 10.1016/j.cgh.2013.06.016. Epub 2013 Jul 12.


Background & aims: Patients with chronic pancreatitis may be at high risk for osteoporosis and osteopenia. We performed a systematic review and meta-analysis to determine the prevalence of osteoporosis and osteopenia in patients with chronic pancreatitis.

Methods: Articles were identified from MEDLINE, EMBASE, and SCOPUS databases (through October 2012) and a manual search of the literature. The primary outcome measure was bone density, measured by dual-energy X-ray absorptiometry (T-score or Z-score). When available, data on the prevalence of osteopenia, bone mineral density, and bone mineral content also were recorded.

Results: Ten studies including 513 patients were eligible for inclusion. Based on a random-effects model, the pooled prevalence rate for osteoporosis among patients with chronic pancreatitis was 23.4% (95% confidence interval, 16.6-32.0). The pooled prevalence for osteopenia was 39.8% (95% confidence interval, 29.1-51.6). The pooled prevalence rate for either osteoporosis or osteopenia was 65% (95% confidence interval, 54.7-74.0).

Conclusions: Based on meta-analysis, almost 1 of 4 patients with chronic pancreatitis have osteoporosis, and almost two-thirds of patients have either osteoporosis or osteopenia. Osteoporosis and osteopenia are underappreciated sources of morbidity in patients with chronic pancreatitis. Bone health management guidelines are urgently required in patients with chronic pancreatitis.

Keywords: BMC; BMD; BMI; Bone Disease; DXA; Demineralization; Metabolic; Risk Factor; body mass index; bone mineral content; bone mineral density; dual-energy X-ray absorptiometry.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Body Mass Index
  • Bone Density / physiology
  • Bone Diseases, Metabolic / epidemiology*
  • Humans
  • Osteoporosis / epidemiology*
  • Pancreatitis, Chronic / epidemiology*
  • Prevalence
  • Risk Factors
  • Smoking / epidemiology