Abstract
The complexation with organoruthenium fragments confers 4-anilinoquinazoline pharmacophores with higher potential for inducing cellular apoptosis while the highly inhibitory activity of 4-anilinoquinazolines against EGFR and the reactivity of the ruthenium centre to 9-ethylguanine are well preserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aniline Compounds / chemistry*
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects*
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Cell Proliferation / drug effects
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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ErbB Receptors / antagonists & inhibitors
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Humans
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Hydrolysis
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MCF-7 Cells
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Models, Molecular
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Molecular Structure
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Organometallic Compounds / chemical synthesis
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology*
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Quinazolines / chemistry*
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Ruthenium / chemistry*
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Structure-Activity Relationship
Substances
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Aniline Compounds
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Antineoplastic Agents
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Organometallic Compounds
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Quinazolines
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Ruthenium
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ErbB Receptors