Iridium-catalyzed hydrogen transfer: synthesis of substituted benzofurans, benzothiophenes, and indoles from benzyl alcohols

Org Lett. 2013 Aug 2;15(15):3876-9. doi: 10.1021/ol401610e. Epub 2013 Jul 16.

Abstract

An iridium-catalyzed hydrogen transfer has been developed in the presence of p-benzoquinone, allowing the synthesis of a diversity of substituted benzofurans, benzothiophenes, and indoles from substituted benzylic alcohols.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzofurans / chemical synthesis*
  • Benzofurans / chemistry*
  • Benzyl Alcohols / chemical synthesis*
  • Benzyl Alcohols / chemistry*
  • Catalysis
  • Indoles / chemical synthesis*
  • Indoles / chemistry*
  • Iridium / chemistry*
  • Molecular Structure
  • Stereoisomerism
  • Thiophenes / chemical synthesis*
  • Thiophenes / chemistry*

Substances

  • Benzofurans
  • Benzyl Alcohols
  • Indoles
  • Thiophenes
  • benzothiophene
  • Iridium