Genetic associations with hypertension: meta-analyses of six candidate genetic variants

Genet Test Mol Biomarkers. 2013 Oct;17(10):736-42. doi: 10.1089/gtmb.2013.0080. Epub 2013 Jul 16.


Aims: The aim of this study was to perform combined analyses of six genetic variants for the risk of hypertension.

Methods: After a comprehensive literature search for genetic variants involved with the association study of hypertension, we harvested a total of five genes (six variants) for the current meta-analyses. These genes consisted of CYP4A11 (T8590C), RGS2 (1891-1892del TC and G638A), HTR2A (T102C), GNAS (T393C), and HSD3B1 (T→C Leu338).

Results: A total of 20 studies among 13,816 cases and 19,248 controls were retrieved for the meta-analyses of six genetic variants. It was shown that the RGS2 1891-1892del TC (OR=1.10, 95% CI=1.02-1.19, p=0.02) polymorphism and the CYP4A11 T8590C (OR=1.19, 95% CI=1.00-1.41, p=0.05) polymorphism were significantly associated with increased risk of hypertension. No association was found between the other four variants and the risk of hypertension.

Conclusion: This meta-analysis revealed that the RGS2 1891-1892del TC polymorphism and CYP4A11 T8590C polymorphism were associated with hypertension risk. However, HSD3B1 T→C Leu338, HTR2A T102C, GNAS T393C, and RGS2 G638A polymorphisms were not associated with hypertension risk.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Female
  • Humans
  • Hypertension / genetics*
  • Male
  • Polymorphism, Genetic*
  • Risk Factors