Alcohol consumption and risk of stroke and coronary heart disease among Japanese women: the Japan Public Health Center-based prospective study

Prev Med. 2013 Nov;57(5):505-10. doi: 10.1016/j.ypmed.2013.07.003. Epub 2013 Jul 13.

Abstract

Objective: The study aims to examine the association between a wide range of alcohol consumption and risk of stroke and coronary heart disease.

Methods: The Japan Public Health Center-based prospective study was initiated in 1990 in Cohort I and in 1993 in Cohort II, with follow-up until 2009. The sample consisted of 47,100 women aged 40-69 years.

Results: During an average of 16.7-years, the incidence of 1846 strokes and 292 coronary heart diseases was observed. Heavy drinking (≥ 300 gethanol/week) was associated with increased risk of total stroke. The multivariable hazard ratios for heavy versus occasional drinkers were 2.19 (95% confidence interval: 1.45-3.30) for total stroke, 2.25 (1.29-3.91) for hemorrhagic stroke, 2.24 (1.05-4.76) for intraparenchymal hemorrhage, 2.26 (1.01-5.09) for subarachnoid hemorrhage and 2.04 (1.09-3.82) for ischemic stroke. In the exposure-updated analysis, the positive association between heavy drinking and risks of total stroke, hemorrhagic stroke and intraparenchymal hemorrhage became more evident. Light drinking (<150 gethanol/week) was not associated with risk of ischemic stroke. There was also no association between alcohol consumption and risk of coronary heart disease.

Conclusion: Heavy drinking was associated with increased risk of hemorrhagic and ischemic strokes among Japanese women.

Keywords: Alcohol consumption; Coronary heart disease; Follow-up study; Incidence; Stroke.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alcohol Drinking / adverse effects*
  • Alcohol Drinking / epidemiology*
  • Alcoholism / complications*
  • Alcoholism / epidemiology
  • Cohort Studies
  • Coronary Disease / epidemiology*
  • Coronary Disease / etiology*
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Health Surveys
  • Humans
  • Japan
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Statistics as Topic
  • Stroke / epidemiology*
  • Stroke / etiology*