Abstract
Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage-doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Antibiotics, Antineoplastic / administration & dosage*
-
Antibiotics, Antineoplastic / pharmacology
-
Archaeal Proteins / chemistry*
-
Archaeal Proteins / genetics
-
Carcinoma, Hepatocellular / drug therapy*
-
Carcinoma, Hepatocellular / pathology
-
Cell Line, Tumor
-
Doxorubicin / administration & dosage*
-
Doxorubicin / pharmacology
-
Drug Carriers / chemistry
-
Heat-Shock Proteins, Small / chemistry*
-
Heat-Shock Proteins, Small / genetics
-
Humans
-
Liver Neoplasms / drug therapy*
-
Liver Neoplasms / pathology
-
Methanocaldococcus / chemistry*
-
Methanocaldococcus / genetics
-
Models, Molecular
-
Molecular Sequence Data
-
Nanostructures / chemistry
-
Protein Engineering
Substances
-
Antibiotics, Antineoplastic
-
Archaeal Proteins
-
Drug Carriers
-
Heat-Shock Proteins, Small
-
Doxorubicin