Route of sexual exposure is independently associated with seropositivity to HPV-16 and HPV-18 among clients of an STI clinic in the Netherlands

J Infect Dis. 2013 Oct 1;208(7):1081-5. doi: 10.1093/infdis/jit295. Epub 2013 Jul 15.


We investigated the route of sexual exposure as a determinant for human papillomavirus (HPV)-16 and HPV-18 seropositivity. At the Amsterdam sexually transmitted infections clinic we recruited 4 risk groups: (1) men who have sex with women only (MSW; n = 751); (2) women who have sex with men (WSM; n = 749); (3) men who have sex with men (MSM) reporting insertive anal sex only (insMSM; n = 156); and (4) MSM reporting receptive anal sex (recMSM; n = 415). In multivariable analyses, HPV-16 seropositivity was significantly more common in WSM vs MSW, recMSM vs MSW, and recMSM vs insMSM. HPV-18 results were similar. Route of sexual exposure is independently associated with HPV seropositivity.

Keywords: HPV; HPV antibodies; STI; men who have sex with men (MSM); route of sexual exposure; seroprevalence; the Netherlands.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Human papillomavirus 16 / immunology*
  • Human papillomavirus 18 / immunology*
  • Humans
  • Male
  • Middle Aged
  • Netherlands / epidemiology
  • Papillomavirus Infections / epidemiology*
  • Papillomavirus Infections / virology*
  • Seroepidemiologic Studies
  • Sexual Behavior*
  • Sexually Transmitted Diseases, Viral / epidemiology*
  • Sexually Transmitted Diseases, Viral / virology*
  • Young Adult