A history of the development of Brucella vaccines

Biomed Res Int. 2013;2013:743509. doi: 10.1155/2013/743509. Epub 2013 Jun 3.


Brucellosis is a worldwide zoonosis affecting animal and human health. In the last several decades, much research has been performed to develop safer Brucella vaccines to control the disease mainly in animals. Till now, no effective human vaccine is available. The aim of this paper is to review and discuss the importance of methodologies used to develop Brucella vaccines in pursuing this challenge.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brucella Vaccine / history*
  • Brucella Vaccine / immunology
  • Brucellosis / immunology
  • Brucellosis / prevention & control
  • Disease Eradication
  • History, 20th Century
  • Humans
  • Vaccines, Subunit / immunology


  • Brucella Vaccine
  • Vaccines, Subunit