This study reports an unusual case of repeated anaphylactic episodes to orange and apple without clinical evidence of primary sensitization to peach LTP. In vitro and in vivo tests revealed heat stability of the implicated allergens and also provided new evidence of differences in allergenicity among apple varieties and strong cross reactivity of citrus fruits. "Prick-to-prick" method with fresh fruits proved to be a quick and advantageous tool in investigating allergy to fresh fruits.