Effect of omega-3 dietary supplements with different oxidation levels in the lipidic profile of women: a randomized controlled trial

Int J Food Sci Nutr. 2013 Dec;64(8):993-1000. doi: 10.3109/09637486.2013.812619. Epub 2013 Jul 18.


The oxidation level of omega-3 fatty acid supplements commercialized in capsules may be a risk to consumers' health. For this purpose, we have designed a single-blind, parallel-group, randomized controlled trial in which 52 women participated. Volunteers were randomly distributed into three groups consuming: (1) less oxidized oil pills, (2) highly oxidized oil pills and (3) no capsules. All groups consumed a fish-rich diet. Circulating glucose, total cholesterol, triglycerides and glutamic pyruvic transaminase were determined at the beginning and end (30 days) of the study. As a result, the ingestion of less oxidized ω-3 supplements reduced circulating triglyceride and cholesterol levels, as opposed to the highly oxidized omega-3 capsules, which had a negative effect on cholesterol levels. In conclusion, the level of oxidation of the supplements is a key factor in controlling circulating lipid profile. Therefore, manufacturers must pay attention to the quality of the prime product prior to encapsulation.

Trial registration: ClinicalTrials.gov NCT01799720.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cholesterol / blood*
  • Diet
  • Dietary Fats / metabolism
  • Dietary Fats / pharmacology*
  • Dietary Supplements / standards*
  • Fatty Acids, Omega-3 / metabolism
  • Fatty Acids, Omega-3 / pharmacology*
  • Female
  • Fish Oils / metabolism
  • Fish Oils / pharmacology
  • Humans
  • Middle Aged
  • Oxidation-Reduction
  • Seafood
  • Single-Blind Method
  • Triglycerides / blood*


  • Dietary Fats
  • Fatty Acids, Omega-3
  • Fish Oils
  • Triglycerides
  • Cholesterol

Associated data

  • ClinicalTrials.gov/NCT01799720