Non-canonical activity of retinoic acid in epigenetic control of embryonic stem cell

Transcription. 2013 Jul-Aug;4(4):158-61. doi: 10.4161/trns.25395. Epub 2013 Jun 14.

Abstract

Non-canonical cytoplasmic activities and signal transduction of retinoic acid (RA) expand RA's pleiotropic effects in coordinating the epigenome in embryonic stem cell (ESC). Examples include RA-bound cellular retinoic acid binding protein I, which activates ERK2. By engaging both cytosolic and nuclear mediators, RA can efficiently augment ESC's epigenome.

Keywords: CRABPI; ERK; OCT4; TR2; embryonic stem cell; epigenetic; retinoic acid.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Nucleus / metabolism
  • Cytosol / metabolism
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / drug effects
  • Embryonic Stem Cells / metabolism*
  • Epigenesis, Genetic / drug effects*
  • Humans
  • Mitogen-Activated Protein Kinase 1 / metabolism
  • Octamer Transcription Factor-3 / metabolism
  • Receptors, Retinoic Acid / metabolism
  • Signal Transduction / drug effects
  • Tretinoin / pharmacology*

Substances

  • Octamer Transcription Factor-3
  • Receptors, Retinoic Acid
  • retinoic acid binding protein I, cellular
  • Tretinoin
  • Mitogen-Activated Protein Kinase 1