A new role for an old player: steroid receptor RNA Activator (SRA) represses hormone inducible genes

Transcription. 2013 Jul-Aug;4(4):167-71. doi: 10.4161/trns.25777. Epub 2013 Jul 1.

Abstract

In breast cancer cells the Steroid Receptor ¬RNA Activator (SRA) acts as scaffold of a complex containing HP1γ, LSD1, HDAC1/2 and CoREST, which contributes to repression of key hormone-inducible genes that must be kept silent in the absence of hormone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromobox Protein Homolog 5
  • Chromosomal Proteins, Non-Histone / metabolism
  • Co-Repressor Proteins / metabolism
  • Histone Deacetylase 1 / metabolism
  • Histone Deacetylase 2 / metabolism
  • Histone Demethylases / metabolism
  • Histones / metabolism
  • Hormones / metabolism
  • Hormones / pharmacology
  • Humans
  • MCF-7 Cells
  • Mice
  • Nerve Tissue Proteins / metabolism
  • RNA, Long Noncoding / genetics
  • RNA, Long Noncoding / metabolism*
  • Transcription, Genetic / drug effects

Substances

  • Chromosomal Proteins, Non-Histone
  • Co-Repressor Proteins
  • Histones
  • Hormones
  • Nerve Tissue Proteins
  • RCOR1 protein, human
  • RNA, Long Noncoding
  • steroid receptor RNA activator
  • Chromobox Protein Homolog 5
  • Histone Demethylases
  • KDM1A protein, human
  • Histone Deacetylase 1
  • Histone Deacetylase 2