Abstract
In breast cancer cells the Steroid Receptor ¬RNA Activator (SRA) acts as scaffold of a complex containing HP1γ, LSD1, HDAC1/2 and CoREST, which contributes to repression of key hormone-inducible genes that must be kept silent in the absence of hormone.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chromobox Protein Homolog 5
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Chromosomal Proteins, Non-Histone / metabolism
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Co-Repressor Proteins / metabolism
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Histone Deacetylase 1 / metabolism
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Histone Deacetylase 2 / metabolism
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Histone Demethylases / metabolism
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Histones / metabolism
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Hormones / metabolism
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Hormones / pharmacology
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Humans
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MCF-7 Cells
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Mice
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Nerve Tissue Proteins / metabolism
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RNA, Long Noncoding / genetics
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RNA, Long Noncoding / metabolism*
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Transcription, Genetic / drug effects
Substances
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Chromosomal Proteins, Non-Histone
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Co-Repressor Proteins
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Histones
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Hormones
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Nerve Tissue Proteins
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RCOR1 protein, human
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RNA, Long Noncoding
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steroid receptor RNA activator
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Chromobox Protein Homolog 5
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Histone Demethylases
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KDM1A protein, human
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Histone Deacetylase 1
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Histone Deacetylase 2