Reference values of serum rheumatoid factor in coastal residents

Clin Lab. 2013;59(5-6):505-9. doi: 10.7754/clin.lab.2012.120609.


Background: This study aims to investigate the reference values of serum rheumatoid factor (RF) in coastal residents.

Methods: We collected 1,762 serum samples from 20 - 69 year-old males who participated in the population-based Fangchenggang Area Male Health and Examination Survey from September 2009 to December 2009. The values of serum RF were measured by immunoturbidimetry.

Results: The established normal reference value range of serum RF (< or = 18.90 IU/mL) in healthy adult males who live in coastal areas is lower than the current value that is extensively used (20 IU/mL). Age, ethnicity, and smoking specific reference values were calculated. Differences were found within groups, but no significant difference in drinking was observed.

Conclusions: It is suggested that every special region should establish respective normal reference values of serum RF in healthy individuals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • China
  • Clinical Chemistry Tests / standards*
  • Cohort Studies
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Nephelometry and Turbidimetry
  • Reference Values
  • Residence Characteristics
  • Rheumatoid Factor / blood*
  • Statistics, Nonparametric


  • Rheumatoid Factor