Background: This study aims to investigate the reference values of serum rheumatoid factor (RF) in coastal residents.
Methods: We collected 1,762 serum samples from 20 - 69 year-old males who participated in the population-based Fangchenggang Area Male Health and Examination Survey from September 2009 to December 2009. The values of serum RF were measured by immunoturbidimetry.
Results: The established normal reference value range of serum RF (< or = 18.90 IU/mL) in healthy adult males who live in coastal areas is lower than the current value that is extensively used (20 IU/mL). Age, ethnicity, and smoking specific reference values were calculated. Differences were found within groups, but no significant difference in drinking was observed.
Conclusions: It is suggested that every special region should establish respective normal reference values of serum RF in healthy individuals.