[Fibrinolytic peptidases of Bacillus]

Mikrobiol Z. May-Jun 2013;75(3):80-93.
[Article in Ukrainian]


The fibrinolytic enzymes are peptidases, which belong to the class of hydrolytic enzymes. They are able to dissolve the insoluble fibrin. This review presents the fibrinolytic peptidases of Bacillus. The methods of increasing biosynthesis of these enzymes, determination of their activity, isolation and purification have been observed. The fibrinolytic peptidases of Bacillus are serine- and metallopeptidases. Its can hydrolyze both the natural substrates (fibrin, fibrinogen and hemoglobin) and synthetic substrates. The high stability of these enzymes in a wide range of pH (5-12) and temperature (10-75 degrees C) permits using them in pharmacology, medicine for the prevention and treatment of cardiovascular diseases.

Publication types

  • Review

MeSH terms

  • Bacillus / enzymology*
  • Fibrinolysis / physiology*
  • Peptide Hydrolases / biosynthesis*
  • Peptide Hydrolases / physiology
  • Substrate Specificity


  • Peptide Hydrolases