NLRP3 inflammasome activation: CD36 serves double duty

Nat Immunol. 2013 Aug;14(8):772-4. doi: 10.1038/ni.2668.

Abstract

Recent studies implicate the NLRP3 inflammasome pathway in elaborating sterile inflammation. CD36 serves a dual role by priming Il1b transcription and inducing assembly of the NLRP3 inflammasome complex, leading to the release of active IL-1β.

Publication types

  • Comment

MeSH terms

  • Alzheimer Disease / immunology*
  • Animals
  • Atherosclerosis / immunology*
  • CD36 Antigens / immunology*
  • Carrier Proteins / immunology*
  • Diabetes Mellitus, Type 2 / immunology*
  • Inflammation / immunology*
  • NLR Family, Pyrin Domain-Containing 3 Protein

Substances

  • CD36 Antigens
  • Carrier Proteins
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human