Preparation and characterization of nocodazole-loaded solid lipid nanoparticles

Pharm Dev Technol. 2014 Sep;19(6):671-6. doi: 10.3109/10837450.2013.819017. Epub 2013 Jul 22.

Abstract

Nocodazole (NCD) has more carcinogenic effect than similar drugs. Moreover, it has low drug release time and high particle size. Solid Lipid Nanoparticles (SLNs) have been evaluated for decrease in particle size and therefore increase in drug release time, for such drugs. In this study, NCD has been successfully incorporated into SLNs systems and remained stable for a period of 90 days. NCD structure related to the chemical nature of solid lipid is a key factor to decide whether anticarcinogenic agent will be incorporated in the long term and for a controlled optimization of active ingredient incorporation and loading, intensive characterization of the physical state of the lipid particles were highly essential. Thus, NMR, FT-IR, DSC (for thermal behavior) analyses were performed and the results did not indicate any problem on stability. Moreover, SLNs were decreased size of NCD in addition to increase in time of the drug release. After SLN preparation, particle size, polydispersity index, electrical conductivity and zeta potential were measured and drug release from NCD-loaded SLNs were performed. These values seem to be of the desired range.

MeSH terms

  • Drug Stability
  • Lipids / chemistry*
  • Nanoparticles / chemistry*
  • Nocodazole / chemistry*
  • Particle Size

Substances

  • Lipids
  • Nocodazole