Risk factors for acquisition of multidrug-resistant Acinetobacter baumannii among cancer patients

Am J Infect Control. 2013 Dec;41(12):1249-52. doi: 10.1016/j.ajic.2013.04.003. Epub 2013 Jul 17.


Background: Data regarding multidrug-resistant (MDR) Acinetobacter baumannii infections among cancer patients are limited.

Methods: We conducted a case-control study to investigate the risk factors for acquisition of MDR A baumannii and the outcomes among cancer patients. Cases were inpatients with malignancy who had MDR A baumannii from any cultures between 2008 and 2011. Controls were inpatients with malignancy but no MDR A baumannii.

Results: A total of 31 case patients were matched with 62 control patients. Hematologic malignancy (P = .036), need for dialysis (P = .01), admission for other reasons except elective surgery (P = .03), transfer from other health care facilities (P = .02), prolonged intensive care unit stay (P = .004), mechanical ventilation (P < .001), pressor use (P = .001), tube feeding (P < .001), transfusion (P = .009), and prior antimicrobial use (P < .001) were identified as significant risk factors in univariate analysis. Need for dialysis (odds ratio [OR], 18.23; P = .04) and prolonged intensive care unit stay (OR, 19.28; P = .01) remained significant in multivariate analysis. Lengths of stay were 28 days for the case patients and 10 days for the control patients (P = .001). The 90-day mortality rates were 41.9% and 29.0%, respectively (P = .20).

Conclusions: Acquisition of MDR A baumannii among cancer patients appears to be associated with general nosocomial infection risk factors rather than underlying malignancies.

Keywords: Case-control study; Clinical outcome; Colonization; Infection; Malignancy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / microbiology*
  • Acinetobacter baumannii / drug effects*
  • Acinetobacter baumannii / isolation & purification*
  • Aged
  • Case-Control Studies
  • Cross Infection / transmission*
  • Drug Resistance, Multiple, Bacterial*
  • Female
  • Humans
  • Inpatients
  • Male
  • Middle Aged
  • Neoplasms / complications*
  • Risk Factors