The secretome of mesenchymal stem cells: potential implications for neuroregeneration

Biochimie. 2013 Dec;95(12):2246-56. doi: 10.1016/j.biochi.2013.07.013. Epub 2013 Jul 19.


Mesenchymal stem cells have shown regenerative properties in many tissues. This feature had originally been ascribed to their multipotency and thus their ability to differentiate into tissue-specific cells. However, many researchers consider the secretome of mesenchymal stem cells the most important player in the observed reparative effects of these cells. In this review, we specifically focus on the potential neuroregenerative effect of mesenchymal stem cells, summarize several possible mechanisms of neuroregeneration and list key factors mediating this effect. We illustrate examples of mesenchymal stem cell treatment in central nervous system disorders including stroke, neurodegenerative disorders (such as Parkinson's disease, Huntington's disease, multiple system atrophy and cerebellar ataxia) and inflammatory disease (such as multiple sclerosis). We specifically highlight studies where mesenchymal stem cells have entered clinical trials.

Keywords: Mesenchymal stem cells; Neuroregeneration; Parkinson's disease; Perivascular niche; Stroke.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Differentiation
  • Humans
  • Mesenchymal Stem Cells / metabolism*
  • Multiple Sclerosis / therapy
  • Nerve Regeneration*
  • Neurodegenerative Diseases / therapy*
  • Neurogenesis / physiology
  • Paracrine Communication / physiology
  • Proteome / metabolism*
  • Stroke / therapy


  • Proteome