Vitamin B₂: a promising adjuvant in cisplatin based chemoradiotherapy by cellular redox management

Food Chem Toxicol. 2013 Sep;59:715-23. doi: 10.1016/j.fct.2013.07.018. Epub 2013 Jul 17.

Abstract

Cancer has been a big challenge in the clinical research arena for many years. All the major anticancer drugs are either not effective or induce serious side effects. Cisplatin (CP) is one of the most valued anticancer drugs against various forms of cancer but it exerts many side effects often resulting in withdrawal of clinical usage during long-term chemotherapy. Thus, increasing the efficacy of the drugs and minimizing deleterious side effects is needed. Vitamins like riboflavin (RF) are promising under photodynamic therapy in this aspect because of its potential as an efficient adjuvant confirmed in many cancer cell lines and animal-based studies. It has been found to alleviate CP-induced side effects significantly under photoillumination in mice. As CP exerts most of its toxic effects by oxidative and nitrosative stress; clubbing ribophototherapy with chemotherapy involving CP can shift the redox status favoring better cancer treatment. This strategy can not only increase the average life span of the cancer patients but also improve their quality of life significantly. However, cancer is still considered as a disease of genetic and metabolic disorders; hence, attacking both aspects of the disease can give better results as compared to contemporary treatment modalities.

Keywords: Cancer; Cisplatin; Free radicals; Riboflavin; Ribophototherapy; Stress.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chemoradiotherapy, Adjuvant* / adverse effects
  • Cisplatin / adverse effects
  • Cisplatin / therapeutic use*
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / therapy*
  • Oxidation-Reduction
  • Photosensitizing Agents / adverse effects
  • Photosensitizing Agents / therapeutic use*
  • Phototherapy / adverse effects
  • Radiation-Sensitizing Agents / adverse effects
  • Radiation-Sensitizing Agents / therapeutic use*
  • Reactive Nitrogen Species / antagonists & inhibitors
  • Reactive Nitrogen Species / metabolism
  • Reactive Oxygen Species / antagonists & inhibitors
  • Reactive Oxygen Species / metabolism
  • Riboflavin / adverse effects
  • Riboflavin / therapeutic use*

Substances

  • Photosensitizing Agents
  • Radiation-Sensitizing Agents
  • Reactive Nitrogen Species
  • Reactive Oxygen Species
  • Cisplatin
  • Riboflavin