Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
, 34 (6), 3701-4

High Plasma D-dimer Level Is Associated With Decreased Survival in Patients With Lung Cancer: A Meta-Analysis

Affiliations
Meta-Analysis

High Plasma D-dimer Level Is Associated With Decreased Survival in Patients With Lung Cancer: A Meta-Analysis

Yong-Xin Zhou et al. Tumour Biol.

Abstract

An elevated plasma D-dimer level indicates the activation of coagulation and fibrinolysis. Several studies suggested that high level of plasma D-dimer was associated with the prognosis of lung cancer. In the present study, we performed a meta-analysis to evaluate the relationship between plasma D-dimer level and the prognosis of lung cancer based on larger sample size. We retrieved the literature, assessed and selected the data, and performed the statistical analysis according to the RevMan 5.0 guidelines. Literature-based searching was guided to gather data, and fixed-effects model was used to pool the hazard ratio according to the test of heterogeneity. A total of seven eligible studies including 1,377 lung cancer patients were analyzed. Survival time was significantly better in patients in the low D-dimer group than those in the high D-dimer group (hazard ratio for high D-dimer group = 1.12; 95% confidence interval 1.02 to 1.23). Patients with high levels of D-dimer have a poorer overall survival compared with those patients with low levels of D-dimer.

Comment in

Similar articles

See all similar articles

Cited by 15 articles

See all "Cited by" articles

References

    1. Thromb Haemost. 2002 Nov;88(5):745-9 - PubMed
    1. Thorac Cancer. 2011 Nov;2(4):207-212 - PubMed
    1. Blood. 2010 Dec 9;116(24):5377-82 - PubMed
    1. Multidiscip Respir Med. 2010 Jun 30;5(3):168-72 - PubMed
    1. Thromb Res. 2000 Feb 1;97(3):105-11 - PubMed

Publication types

Substances

LinkOut - more resources

Feedback