Association of a particular amino acid sequence of the HLA-DR beta 1 chain with HTLV-I-associated myelopathy

Eur J Immunol. 1990 Jul;20(7):1603-6. doi: 10.1002/eji.1830200729.


Analyses of HLA-DRB1 gene using polymerase chain reaction and sequence-specific oligonucleotide probes reveal that the amino acid sequence Glu-Gln-Arg-Arg-Ala-Ala-Val at positions 69-75 of the third hypervariable region (HVR) of HLA-DR beta 1 chain is significantly associated with HTLV-I-associated myelopathy (HAM). Since the frequency of this sequence in HTLV-I carriers is almost the same as that in controls from Kagoshima (an endemic area of HTLV-I), this sequence may be related to susceptibility to HAM rather than to susceptibility to HTLV-I infection. Since this third HVR functions as putative antigen-binding sites and T cell recognition sites, the amino acid sequence of positions 68-73 was analyzed in detail. The analysis reveals that Gln70 and Arg71 are relevant to the occurrence of HAM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Base Sequence
  • Genetic Predisposition to Disease
  • HLA-DR Antigens / genetics*
  • Humans
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Oligonucleotide Probes
  • Paraparesis, Tropical Spastic / genetics
  • Paraparesis, Tropical Spastic / immunology*
  • Polymerase Chain Reaction


  • HLA-DR Antigens
  • Oligonucleotide Probes