[Subclinical hyperthyroidism]

Dtsch Med Wochenschr. 2013 Oct;138(42):2146-50. doi: 10.1055/s-0033-1343278. Epub 2013 Jul 19.
[Article in German]


Subclinical hyperthyroidism is defined as abnormal low TSH level with thyroid hormones within their reference range. This laboratory condition may be symptomatic in a relevant number of patients leading to tachycardia, sweating, nervousness, anxiety and insomnia. The risk for cardiovascular disease is increased with more frequent atrial fibrillation and increased left ventricular mass including diastolic dysfunction. Cardiovascular mortality and overall mortality surmounts the average of the normal population. Longterm TSH suppression leads to decreased bone mineral density and an increased fracture rate in the hip and in the spine. After evaluation of underlying causes, therapy should be considered, especially if TSH levels are below 0.1 mIU/l.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antithyroid Agents / adverse effects
  • Antithyroid Agents / therapeutic use
  • Bone Density / drug effects
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / mortality
  • Cause of Death
  • Diagnosis, Differential
  • Female
  • Humans
  • Hyperthyroidism / blood
  • Hyperthyroidism / diagnosis*
  • Hyperthyroidism / etiology
  • Hyperthyroidism / mortality
  • Male
  • Mass Screening
  • Middle Aged
  • Reference Values
  • Risk Factors
  • Survival Analysis
  • Thyrotropin / blood*


  • Antithyroid Agents
  • Thyrotropin