The nuclear envelope LEM-domain protein emerin

Nucleus. Jul-Aug 2013;4(4):298-314. doi: 10.4161/nucl.25751. Epub 2013 Jul 17.

Abstract

Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge--biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to human disease--is available. This review summarizes emerin and its emerging roles in nuclear "lamina" structure, chromatin tethering, gene regulation, mitosis, nuclear assembly, development, signaling and mechano-transduction. We also highlight many open questions, exploration of which will be critical to understand how this intriguing nuclear membrane protein and its "family" influence the genome.

Keywords: Emery-Dreifuss muscular dystrophy; GAGE cancer-testis antigen; LEM-domain; Nestor-Guillermo progeria; O-GlcNAc transferase; barrier-to-autointegration factor; emerin; laminopathy; nuclear envelope; nucleoskeleton.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism*
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Nuclear Envelope / metabolism*
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*

Substances

  • Membrane Proteins
  • Nuclear Proteins
  • emerin