Fatal neurological side-effects with necrosis of spinal cord following nelarabine treatment in a child with relapsed T-cell acute lymphoblastic leukemia

Am J Hematol. 2013 Dec;88(12):1096-7. doi: 10.1002/ajh.23550. Epub 2013 Sep 12.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Antimetabolites, Antineoplastic / administration & dosage
  • Antimetabolites, Antineoplastic / adverse effects*
  • Arabinonucleosides / administration & dosage
  • Arabinonucleosides / adverse effects*
  • Cerebellum / drug effects
  • Cerebellum / pathology
  • Child
  • Cyclophosphamide / administration & dosage
  • Cytarabine / administration & dosage
  • Etoposide / administration & dosage
  • Fatal Outcome
  • Guillain-Barre Syndrome / chemically induced*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Medulla Oblongata / drug effects
  • Medulla Oblongata / pathology
  • Methotrexate / administration & dosage
  • Necrosis
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Prednisolone / administration & dosage
  • Recurrence
  • Seizures / chemically induced*
  • Spinal Cord / drug effects
  • Spinal Cord / pathology*

Substances

  • Antimetabolites, Antineoplastic
  • Arabinonucleosides
  • Cytarabine
  • nelarabine
  • Etoposide
  • Cyclophosphamide
  • Prednisolone
  • Methotrexate