doi: 10.1016/0014-5793(90)81149-i.
Cloning of the human brain GABA transporter
Affiliations
- PMID: 2387399
- DOI: 10.1016/0014-5793(90)81149-i
Item in Clipboard
Cloning of the human brain GABA transporter
FEBS Lett.
.
Free article
Abstract
A cDNA clone encoding a transporter for the neurotransmitter gamma-aminobutyric acid in human brain was cloned and sequenced. The cDNA contains an open reading frame encoding a hydrophobic protein of 599 amino acids with a calculated molecular weight of 67022 Da. Hydropathy analysis revealed twelve potential transmembrane segments. The human protein is highly homologous to the protein from rat brain. Northern hybridization demonstrated a ubiquitous distribution of the transporter in various parts of the brain.
Similar articles
-
Expression of a mouse brain cDNA encoding novel gamma-aminobutyric acid transporter.J Biol Chem. 1992 Sep 5;267(25):17491-3. J Biol Chem. 1992. PMID: 1517200
-
Cloning and expression of a rat brain GABA transporter.Science. 1990 Sep 14;249(4974):1303-6. doi: 10.1126/science.1975955. Science. 1990. PMID: 1975955
-
Cloning and expression of a betaine/GABA transporter from human brain.J Neurochem. 1995 Mar;64(3):977-84. doi: 10.1046/j.1471-4159.1995.64030977.x. J Neurochem. 1995. PMID: 7861179
-
Amino acid neurotransmitter reuptake: mechanistics, biochemistry and molecular cloning.Biochem Soc Trans. 1991 Feb;19(1):92-5. doi: 10.1042/bst0190092. Biochem Soc Trans. 1991. PMID: 2037206 Review. No abstract available.
-
Structure, function and brain localization of neurotransmitter transporters.J Exp Biol. 1994 Nov;196:283-95. doi: 10.1242/jeb.196.1.283. J Exp Biol. 1994. PMID: 7823028 Review.
Cited by
-
A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain.Front Physiol. 2023 Apr 13;14:1145973. doi: 10.3389/fphys.2023.1145973. eCollection 2023. Front Physiol. 2023. PMID: 37123280 Free PMC article. Review.
-
Anxiolytics for Bronchodilation: Refinements to GABAA Agonists for Asthma Relief.Am J Respir Cell Mol Biol. 2022 Oct;67(4):419-420. doi: 10.1165/rcmb.2022-0287ED. Am J Respir Cell Mol Biol. 2022. PMID: 35901197 Free PMC article. No abstract available.
-
Genome-Wide Analysis of the Amino Acid Auxin Permease (AAAP) Gene Family and Identification of an AAAP Gene Associated with the Growth and Reproduction of the Brown Planthopper, Nilaparvata lugens (Stål).Insects. 2021 Aug 18;12(8):746. doi: 10.3390/insects12080746. Insects. 2021. PMID: 34442311 Free PMC article.
-
Influence of glutamate and GABA transport on brain excitatory/inhibitory balance.Exp Biol Med (Maywood). 2021 May;246(9):1069-1083. doi: 10.1177/1535370221989263. Epub 2021 Feb 7. Exp Biol Med (Maywood). 2021. PMID: 33554649 Free PMC article. Review.
-
Amino Acid Transporter SLC6A14 (ATB0,+) - A Target in Combined Anti-cancer Therapy.Front Cell Dev Biol. 2020 Oct 21;8:594464. doi: 10.3389/fcell.2020.594464. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 33195271 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
