Comparison of health-related quality of life and exercise capacity according to stages in patients with non-small cell lung cancer

Tuberk Toraks. 2013;61(2):131-9. doi: 10.5578/tt.5396.


Introduction: The aim of this study is to compare the exercise capacity and health-related quality of life parameters according to stages of patients with non-small cell lung cancer (NSCLC).

Materials and methods: Fifty-two patients (who are able to ambulate independently) with stage I-II (group early-stage, n= 17) and stage IIIA-IV NSCLC (group advanced-stage, n= 35) were included. Exercise capacity (six minute walking test), strength of the peripheral muscle (Back and Leg Dynamometer), performance status (Karnofsky performance status scale), health-related quality of life- HRQOL (European Organization for Research and Treatment of Cancer Quality of life measure and Short Form-36 Health Survey), depression and anxiety (Hospital Anxiety and Depression Scale) were evaluated.

Results: No difference was found in age, body mass index, respiratory symptoms and the distribution of disease cell types between two groups (p> 0.05). In advanced-stage group, pulmonary function test values, peripheral muscle strength, walking distance and health-related quality of life scores especially the categories of functional capacity and pain were established significantly lower compared to early-stage group (p ≤ 0.05). Depression and anxiety levels were confirmed to be similar between groups (p> 0.05).

Conclusion: The exercise capacity of patients with advanced-stage NSCLC is lower due to reduced pulmonary functions and peripheral muscle strength compared to patients with early-stage NSCLC. Therefore, we can conclude that reduced exercise capacity negatively impacts functional categories of health related quality of life of patients with advanced-stage NSCLC.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Anxiety / epidemiology
  • Body Composition
  • Carcinoma, Non-Small-Cell Lung / physiopathology*
  • Carcinoma, Non-Small-Cell Lung / psychology*
  • Depression / epidemiology
  • Exercise / physiology*
  • Female
  • Humans
  • Lung Neoplasms / physiopathology*
  • Lung Neoplasms / psychology*
  • Male
  • Middle Aged
  • Muscle Strength / physiology*
  • Neoplasm Staging
  • Pain / epidemiology
  • Quality of Life*
  • Respiratory Function Tests
  • Severity of Illness Index
  • Walking / physiology