The role of diet in triggering human inflammatory disorders in the modern age

Microbes Infect. 2013 Nov;15(12):765-74. doi: 10.1016/j.micinf.2013.07.004. Epub 2013 Jul 20.


Previously uncommon human inflammatory disorders are emerging with alarming frequency, possibly triggered by environmental factors introduced through Westernization. This review highlights how Western diets heighten the inflammatory state promoting development of disease. Evidence that this can occur directly or indirectly through perturbations of host-microbe interactions are reviewed.

Keywords: Gut microbiota; High-fat; Immunity; Inflammatory disease; Systemic inflammation; Western diet.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / epidemiology*
  • Diet / adverse effects*
  • Host-Pathogen Interactions*
  • Humans
  • Immunity*
  • Inflammatory Bowel Diseases / epidemiology*
  • Metabolic Syndrome / epidemiology*