Cytotoxic and Anti-Tumor Activities of Lignans From the Seeds of Vietnamese Nutmeg Myristica Fragrans

Arch Pharm Res. 2014 Mar;37(3):399-403. doi: 10.1007/s12272-013-0185-4. Epub 2013 Jul 23.

Abstract

Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin A2 and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with IC50 value of 10.1 μM. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cytotoxins / isolation & purification*
  • Cytotoxins / pharmacology
  • Dogs
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • Lignans / isolation & purification*
  • Lignans / pharmacology
  • MCF-7 Cells
  • Madin Darby Canine Kidney Cells
  • Mice
  • Myristica*
  • Seeds*
  • Tumor Burden / drug effects*
  • Tumor Burden / physiology
  • Vietnam
  • Xenograft Model Antitumor Assays / methods

Substances

  • Antineoplastic Agents, Phytogenic
  • Cytotoxins
  • Lignans