New hope for therapy in neurodegenerative diseases

Cell Res. 2013 Oct;23(10):1159-60. doi: 10.1038/cr.2013.96. Epub 2013 Jul 23.


The use of genetic screens to define cellular pathways that regulate neurodegenerative disease proteins has emerged as a powerful strategy to identify potential therapeutic targets for these disorders. Using cross-species genetic screens, Park et al. recently identified RAS-MAPK-MSK1 as a cellular pathway that modulates levels of the polyglutamine-containing protein ATXN1 and its subsequent toxicity in SCA1.

Publication types

  • Comment

MeSH terms

  • Animals
  • Drosophila melanogaster / metabolism*
  • Female
  • Humans
  • Male
  • Mitogen-Activated Protein Kinases / metabolism*
  • Nerve Tissue Proteins / metabolism*
  • Nerve Tissue Proteins / toxicity*
  • Nuclear Proteins / metabolism*
  • Nuclear Proteins / toxicity*
  • Ribosomal Protein S6 Kinases, 90-kDa / metabolism*
  • Spinocerebellar Ataxias / metabolism*
  • Spinocerebellar Ataxias / pathology*
  • ras Proteins / metabolism*


  • Nerve Tissue Proteins
  • Nuclear Proteins
  • Ribosomal Protein S6 Kinases, 90-kDa
  • Mitogen-Activated Protein Kinases
  • ras Proteins