Pradimicins A, B and C: new antifungal antibiotics. I. Taxonomy, production, isolation and physico-chemical properties

K Tomita; M Nishio; K Saitoh; H Yamamoto; Y Hoshino; H Ohkuma; M Konishi; T Miyaki; T Oki

doi:10.7164/antibiotics.43.755

Pradimicins A, B and C: new antifungal antibiotics. I. Taxonomy, production, isolation and physico-chemical properties

J Antibiot (Tokyo). 1990 Jul;43(7):755-62. doi: 10.7164/antibiotics.43.755.

Authors

K Tomita¹, M Nishio, K Saitoh, H Yamamoto, Y Hoshino, H Ohkuma, M Konishi, T Miyaki, T Oki

Affiliation

¹ Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.

PMID: 2387769
DOI: 10.7164/antibiotics.43.755

Abstract

New antifungal antibiotics, pradimicins A, B and C were isolated from the culture broth of actinomycete strains proposed as Actinomadura hibisca. They are orange to red pigments containing a benzo[a]naphthacenequinone chromophore substituted with a D-alanine, an aminosugar and a D-xylose (pradimicins A and C).

MeSH terms

Actinomycetales / classification
Actinomycetales / growth & development
Actinomycetales / metabolism*
Actinomycetales / ultrastructure
Anthracyclines*
Antibiotics, Antineoplastic / analysis
Antibiotics, Antineoplastic / biosynthesis*
Antibiotics, Antineoplastic / isolation & purification
Antifungal Agents / analysis
Antifungal Agents / biosynthesis*
Antifungal Agents / isolation & purification
Chromatography, High Pressure Liquid
Crystallization
Fermentation
Magnetic Resonance Spectroscopy
Microscopy, Electron
Microscopy, Electron, Scanning
Molecular Structure
Soil Microbiology
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet

Substances

Anthracyclines
Antibiotics, Antineoplastic
Antifungal Agents
benanomicin B
pradimicin A
pradimicin B