Abstract
Two polyene macrolide, trichomycins A and B, were compared by physico-chemical and microbiological methods. The two antibiotics were found to have the same molecular formula, C58H84N2O18 (MW 1,096), by elemental analysis and FAB-MS. However, 1H and 13C NMR spectrometry studies indicated that the hydroxyl at C-5 of trichomycin A located on C-9 in trichomycin B. Trichomycin B possessed lower activities against fungi and yeasts than those of trichomycin A.
MeSH terms
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Antifungal Agents / analysis*
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Antifungal Agents / biosynthesis
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Chromatography
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Chromatography, High Pressure Liquid
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Culture Media
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Fermentation
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Fungi / drug effects*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Organic Chemicals*
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Streptomyces / metabolism*
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Yeasts / drug effects
Substances
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Antifungal Agents
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Culture Media
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Organic Chemicals
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hachimycin