LHRH-PE40 fusion protein tethered silica nanorattles for imaging-guided tumor-specific drug delivery and bimodal therapy

Adv Mater. 2013 Oct 11;25(38):5508-13. doi: 10.1002/adma.201301217. Epub 2013 Jul 22.

Abstract

Docyanine green (ICG) and LHRH-PE40 fusion protein are tethered onto drug carriers of silica nanorattles for imaging-guided tumor-specific drug delivery and bimodal therapy. The synergistic therapeutic effect of toxin PE40 and the chemotherapeutic drug docetaxel (Dtxl), specifically directed by LHRH to cancer, improves cancer treatment. Simultaneously, ICG enables real-time monitoring of the silica nanocomposites and therapeutic response.

Keywords: LHRH fusion protein; bimodal therapy; multifunction; nanotheranostics; silica nanorattle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carcinoma, Non-Small-Cell Lung / diagnosis
  • Carcinoma, Non-Small-Cell Lung / pathology*
  • Carcinoma, Non-Small-Cell Lung / therapy
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Drug Carriers / chemistry
  • Drug Carriers / metabolism
  • Drug Carriers / toxicity
  • Exotoxins / genetics*
  • Gonadotropin-Releasing Hormone / chemistry*
  • Gonadotropin-Releasing Hormone / genetics
  • Humans
  • Intracellular Space / metabolism
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / therapy
  • Mice
  • Models, Molecular
  • Molecular Conformation
  • Molecular Imaging
  • Nanocomposites / chemistry*
  • Nanocomposites / toxicity
  • Nanomedicine
  • Pseudomonas aeruginosa
  • Recombinant Fusion Proteins / chemistry*
  • Recombinant Fusion Proteins / genetics
  • Silicon Dioxide / chemistry*

Substances

  • Drug Carriers
  • Exotoxins
  • Recombinant Fusion Proteins
  • Gonadotropin-Releasing Hormone
  • Silicon Dioxide