Colonic Bacterial Metabolites and Human Health

Curr Opin Microbiol. 2013 Jun;16(3):246-54. doi: 10.1016/j.mib.2013.07.002. Epub 2013 Jul 20.

Abstract

The influence of the microbial-mammalian metabolic axis is becoming increasingly important for human health. Bacterial fermentation of carbohydrates (CHOs) and proteins produces short-chain fatty acids (SCFA) and a range of other metabolites including those from aromatic amino acid (AAA) fermentation. SCFA influence host health as energy sources and via multiple signalling mechanisms. Bacterial transformation of fibre-related phytochemicals is associated with a reduced incidence of several chronic diseases. The 'gut-liver axis' is an emerging area of study. Microbial deconjugation of xenobiotics and release of aromatic moieties into the colon can have a wide range of physiological consequences. In addition, the role of the gut microbiota in choline deficiency in non-alcoholic fatty liver disease (NAFLD) and insulin resistance is receiving increased attention.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria / metabolism*
  • Colon / microbiology*
  • Colon / physiology*
  • Dietary Fiber / metabolism
  • Fatty Acids, Volatile / metabolism
  • Health*
  • Humans
  • Metabolome*
  • Microbiota*

Substances

  • Dietary Fiber
  • Fatty Acids, Volatile