CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension

J Hypertens. 2013 Oct;31(10):1939-43. doi: 10.1097/HJH.0b013e328362feb7.


Endothelial dysfunction plays a key role in the development and progression of cardiovascular disease. In patients with hypertension, endothelial dysfunction is characterized by a decrease of vasodilator factors release. Recent evidence highlights the involvement of regulatory T cell in the cardiovascular physiology and pathology. An increasing body of data suggest that an imbalance in the immune system triggers inflammation and compromises the cardiovascular homeostasis. In this mini-review, we will highlight the role of immune regulatory T cells in hypertension-induced vascular dysfunction.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Atherosclerosis / complications
  • Atherosclerosis / immunology
  • Blood Pressure
  • CD4-Positive T-Lymphocytes / immunology*
  • Endothelium, Vascular / pathology
  • Forkhead Transcription Factors / metabolism*
  • Homeostasis
  • Humans
  • Hypertension / complications
  • Hypertension / immunology*
  • Immune Tolerance
  • Inflammation
  • Interleukin-2 Receptor alpha Subunit / metabolism*
  • Mice
  • Microcirculation
  • T-Lymphocytes, Regulatory / immunology*
  • Vascular Diseases / immunology*


  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Interleukin-2 Receptor alpha Subunit