doi: 10.1016/0022-2836(90)90275-Q.
Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins
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- PMID: 2388258
- DOI: 10.1016/0022-2836(90)90275-Q
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Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins
J Mol Biol.
.
Abstract
Double mutant cycles enable the measurement of pairwise interactions in proteins. This method is extended for mutations at any number of positions in the protein. This provides a way for determining the context dependence of pairwise interactions on other neighbouring residues.
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