Study of methacholine positivity in patients with chronic cough at Masih Daneshvari hospital, Tehran, 2007-2008

East Mediterr Health J. 2013 Apr;19(4):369-72.


While airways reactivity is among the characteristics of asthma, it is not considered a sufficient condition diagnostically and the methacholine challenge is a non-specific diagnostic aid in cases of chronic cough and reactive airways disease. The aim of this cross-sectional study was to determine the metacholine response positivity and diagnosis of asthma in patients with chronic cough presenting to a hospital in Tehran during 2007 and 2008. Of 101 patients with chronic cough (with no history of sinusitis, recent pulmonary infection, bronchitis, gasteroesophageal reflux or underlying pulmonary conditions), 51.5% showed reactive airways disease to the methacholine test, 40.6% were unreactive and 7.9% were indeterminate. A positive methacholine challenge test was positively correlated with new wheezing. Although the methacholine challenge test is not a primary test for evaluating chronic cough, if no other reason for chronic cough is found, it may be a guiding test for asthma.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Asthma / diagnosis
  • Asthma / epidemiology*
  • Bronchial Hyperreactivity / diagnosis
  • Bronchial Hyperreactivity / epidemiology*
  • Bronchial Hyperreactivity / metabolism
  • Bronchial Provocation Tests
  • Chronic Disease
  • Cough / epidemiology*
  • Cough / metabolism
  • Cross-Sectional Studies
  • Female
  • Humans
  • Iran / epidemiology
  • Male
  • Methacholine Chloride / metabolism
  • Middle Aged
  • Respiratory Function Tests
  • Respiratory Sounds
  • Young Adult


  • Methacholine Chloride