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Review
. 2013 Aug;13(8):578-91.
doi: 10.1038/nri3487.

New Insights Into pre-BCR and BCR Signalling With Relevance to B Cell Malignancies

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Review

New Insights Into pre-BCR and BCR Signalling With Relevance to B Cell Malignancies

Robert C Rickert. Nat Rev Immunol. .

Erratum in

  • Nat Rev Immunol. 2013 Sep;13(9):701

Abstract

The B cell receptor (BCR) and its precursor (pre-BCR) control B cell homeostasis, differentiation and function. Moreover, aberrant pre-BCR and BCR signalling have a central role in B cell neoplasia; for example, enhanced positive signalling or disrupted negative signalling downstream of the pre-BCR promotes B cell acute lymphocytic leukaemia. The emerging distinctions between tonic and chronic active BCR signalling have contributed to the identification of oncogenic targets downstream of BCR signalling in mature B cell neoplasms. Indeed, the encouraging results of several ongoing clinical trials that target the activity of phosphoinositide 3-kinase δ-isoform (PI3Kδ), Bruton tyrosine kinase (BTK) or spleen tyrosine kinase (SYK) downstream of the BCR highlight the therapeutic potential of inhibiting BCR signalling.

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