Treatment of acne scars with hyaluronic acid: an improved approach

J Drugs Dermatol. 2013 Jul 1;12(7):e121-3.


Background: Acne scarring is a prevalent and challenging cosmetic issue, which is often addressed by multiple modalities. A low-viscosity non-animal stabilized hyaluronic acid (NASHA) dermal filler, injected in microdoses into the mid-to-superficial dermis, may provide a useful new approach to improving the appearance of depressed acne scars

Materials and methods: Twelve consecutive patients with moderate to severe acne scarring, who had completed a series of fractional laser resurfacing, underwent microinjections of 20 mg/mL hyaluronic acid (HA) gel into discrete depressed acne scars on the face

Results: Immediate visual improvement was observed in all lesions. The procedure was well tolerated. Adverse events were limited to transient pinpoint bleeding at the injection site

Conclusion: Microinjection of low viscosity HA offers a valuable technique for the treatment of discrete depressed acne scars

Publication types

  • Clinical Trial

MeSH terms

  • Acne Vulgaris / complications*
  • Adult
  • Cicatrix / etiology
  • Cicatrix / therapy*
  • Combined Modality Therapy
  • Cosmetic Techniques
  • Female
  • Humans
  • Hyaluronic Acid / administration & dosage
  • Hyaluronic Acid / adverse effects
  • Hyaluronic Acid / analogs & derivatives*
  • Laser Therapy / methods*
  • Male
  • Microinjections
  • Middle Aged
  • Severity of Illness Index
  • Treatment Outcome
  • Viscosity
  • Young Adult


  • Hyaluronic Acid
  • Restylane