An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants

Expert Rev Vaccines. 2013 Jul;12(7):747-58. doi: 10.1586/14760584.2013.811188.

Abstract

With the exception of alum, emulsion-based vaccine adjuvants have been administered to far more people than any other adjuvant, especially since the 2009 H1N1 influenza pandemic. The number of clinical safety and immunogenicity evaluations of vaccines containing emulsion adjuvants has correspondingly mushroomed. In this review, the authors introduce emulsion adjuvant composition and history before detailing the most recent findings from clinical and postmarketing data regarding the effects of emulsion adjuvants on vaccine immunogenicity and safety, with emphasis on the most widely distributed emulsion adjuvants, MF59® and AS03. The authors also present a summary of other emulsion adjuvants in clinical development and indicate promising avenues for future emulsion-based adjuvant development. Overall, emulsion adjuvants have demonstrated potent adjuvant activity across a number of disease indications along with acceptable safety profiles.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Adjuvants, Immunologic / administration & dosage*
  • Adjuvants, Immunologic / adverse effects*
  • Adjuvants, Immunologic / chemistry
  • Adjuvants, Immunologic / history
  • Clinical Trials as Topic
  • Drug Combinations
  • Emulsions / administration & dosage*
  • Emulsions / adverse effects*
  • Emulsions / chemistry
  • Emulsions / history
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Polysorbates / administration & dosage
  • Polysorbates / adverse effects
  • Polysorbates / chemistry
  • Polysorbates / history
  • Product Surveillance, Postmarketing
  • Squalene / administration & dosage
  • Squalene / adverse effects
  • Squalene / chemistry
  • Squalene / history
  • Vaccines / administration & dosage
  • Vaccines / adverse effects*
  • Vaccines / immunology*
  • alpha-Tocopherol / administration & dosage
  • alpha-Tocopherol / adverse effects
  • alpha-Tocopherol / chemistry
  • alpha-Tocopherol / history

Substances

  • ASO3B adjuvant
  • Adjuvants, Immunologic
  • Drug Combinations
  • Emulsions
  • MF59 oil emulsion
  • Polysorbates
  • Vaccines
  • Squalene
  • alpha-Tocopherol