Hypoxic-ischemic damage of the basal ganglia. Case reports and a review of the literature

Mov Disord. 1990;5(3):219-24. doi: 10.1002/mds.870050306.


Three cases of movement disorders secondary to hypoxic-ischemic encephalopathy are reported. Despite similarities among the clinical events, the neurological syndromes produced were dissimilar. Cerebral hypoxia-ischemia typically produces lesions of the globus pallidus that may result in an akinetic rigid syndrome. Due to its unique blood supply, vascular insufficiency is found to be a major factor. Lesions in the putamen also occur, and these tend to be associated with dystonia. Recent evidence supports a specific neuronal sensitivity in the striatum, possibly due to afferent excitatory amino acid connections. These two components and changes in the levels of neurotransmitters during hypoxia-ischemia may interact to produce varied clinical outcomes. These factors must also be considered when planning therapeutic interventions.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Basal Ganglia / diagnostic imaging
  • Basal Ganglia / physiopathology*
  • Female
  • Humans
  • Hypoxia, Brain / complications*
  • Middle Aged
  • Movement Disorders / etiology*
  • Movement Disorders / physiopathology
  • Tomography, X-Ray Computed