How Integrins Control Breast Biology

Curr Opin Cell Biol. 2013 Oct;25(5):633-41. doi: 10.1016/j.ceb.2013.06.010. Epub 2013 Jul 22.

Abstract

This article explores new ideas about how the ECM-integrin axis controls normal and malignant breast biology. We discuss the role of integrins in mammary stem cells, and how cell-matrix interactions regulate ductal and alveolar development and function. We also examine the contribution of integrins to tissue disorganisation and metastasis, and how an altered stromal and ECM tumour microenvironment affects the cancer cell niche both within primary tumours and at distant sites. Finally, we mention novel strategies for integrin-directed breast cancer treatment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Breast / cytology
  • Breast / pathology
  • Breast / physiology*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Extracellular Matrix / metabolism
  • Extracellular Matrix / pathology
  • Female
  • Humans
  • Integrins / physiology*
  • Mammary Glands, Animal / cytology
  • Mammary Glands, Animal / pathology
  • Mammary Glands, Animal / physiology
  • Neoplastic Stem Cells / metabolism
  • Tumor Microenvironment

Substances

  • Integrins