Linear reconstruction of perceived images from human brain activity

Neuroimage. 2013 Dec:83:951-61. doi: 10.1016/j.neuroimage.2013.07.043. Epub 2013 Jul 22.


With the advent of sophisticated acquisition and analysis techniques, decoding the contents of someone's experience has become a reality. We propose a straightforward linear Gaussian approach, where decoding relies on the inversion of properly regularized encoding models, which can still be solved analytically. In order to test our approach we acquired functional magnetic resonance imaging data under a rapid event-related design in which subjects were presented with handwritten characters. Our approach is shown to yield state-of-the-art reconstructions of perceived characters as estimated from BOLD responses. This even holds for previously unseen characters. We propose that this framework serves as a baseline with which to compare more sophisticated models for which analytical inversion is infeasible.

Keywords: Image reconstruction; Linear regression; Regularization; fMRI analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / physiology*
  • Brain Mapping / methods*
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Linear Models
  • Magnetic Resonance Imaging
  • Models, Neurological*
  • Visual Perception / physiology*