Concentration memory-dependent synaptic plasticity of a taste circuit regulates salt concentration chemotaxis in Caenorhabditis elegans

Nat Commun. 2013;4:2210. doi: 10.1038/ncomms3210.

Abstract

It is poorly understood how sensory systems memorize the intensity of sensory stimulus, compare it with a newly sensed stimulus, and regulate the orientation behaviour based on the memory. Here we report that Caenorhabditis elegans memorizes the environmental salt concentration during cultivation and exhibits a strong behavioural preference for this concentration. The right-sided amphid gustatory neuron known as ASER, senses decreases in salt concentration, and this information is transmitted to the postsynaptic AIB interneurons only in the salt concentration range lower than the cultivation concentration. In this range, animals migrate towards higher concentration by promoting turning behaviour upon decreases in salt concentration. These observations provide a mechanism for adjusting the orientation behaviour based on the memory of sensory stimulus using a simple neural circuit.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal
  • Caenorhabditis elegans / physiology*
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism
  • Chemotaxis / physiology
  • Gene Expression Regulation
  • Interneurons / cytology
  • Interneurons / physiology
  • Memory / physiology
  • Neuronal Plasticity / physiology
  • Orientation / physiology
  • Sensory Receptor Cells / cytology
  • Sensory Receptor Cells / physiology
  • Signal Transduction
  • Sodium Chloride / metabolism
  • Synapses / physiology
  • Taste / physiology

Substances

  • Caenorhabditis elegans Proteins
  • Sodium Chloride