Dynamic regulation of ubiquitin-dependent cell cycle control

Allison Craney; Michael Rape

doi:10.1016/j.ceb.2013.07.004

Dynamic regulation of ubiquitin-dependent cell cycle control

Curr Opin Cell Biol. 2013 Dec;25(6):704-10. doi: 10.1016/j.ceb.2013.07.004. Epub 2013 Jul 24.

Authors

Allison Craney¹, Michael Rape

Affiliation

¹ Department of Molecular and Cell Biology, University of California, Berkeley, United States.

PMID: 23890701
DOI: 10.1016/j.ceb.2013.07.004

Abstract

Recent work revealed that cullin-RING ligases and the anaphase-promoting complex, two classes of ubiquitin ligases that are essential for cell division in all eukaryotes, are regulated in a highly dynamic manner. Here, we describe mechanisms that establish the dynamic regulation of these crucial ubiquitylation enzymes and discuss the functional consequences for cell division control.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Anaphase-Promoting Complex-Cyclosome / metabolism*
Animals
Cell Cycle Checkpoints*
Cell Division
Cullin Proteins / metabolism
Humans
Substrate Specificity
Ubiquitin / metabolism*
Ubiquitin-Protein Ligases / metabolism*
Ubiquitination

Substances

Cullin Proteins
Ubiquitin
Anaphase-Promoting Complex-Cyclosome
Ubiquitin-Protein Ligases