Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function

Biol Psychiatry. 2014 Mar 1;75(5):e11-3. doi: 10.1016/j.biopsych.2013.06.011. Epub 2013 Jul 25.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Antipsychotic Agents / therapeutic use*
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / metabolism
  • Dihydroxyphenylalanine / analogs & derivatives
  • Dihydroxyphenylalanine / pharmacokinetics
  • Dopamine / metabolism*
  • Female
  • Glutamic Acid / metabolism*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Male
  • Positron-Emission Tomography
  • Protons
  • Schizophrenia / diagnostic imaging
  • Schizophrenia / drug therapy*
  • Schizophrenia / metabolism*

Substances

  • Antipsychotic Agents
  • Protons
  • fluorodopa F 18
  • Aspartic Acid
  • Glutamic Acid
  • Dihydroxyphenylalanine
  • N-acetylaspartate
  • Dopamine